Assessment of the innervation pattern of oral squamous cell carcinoma using neural protein gene product (9.5)–An immunocytochemical study
Identifieur interne : 003251 ( Pmc/Curation ); précédent : 003250; suivant : 003252Assessment of the innervation pattern of oral squamous cell carcinoma using neural protein gene product (9.5)–An immunocytochemical study
Auteurs : Fahed Samir Habash ; Ra D O Abu Hantash ; Mohammed Abu YunisSource :
- Journal of Oral and Maxillofacial Pathology : JOMFP [ 0973-029X ] ; 2012.
Abstract
This study was carried out to assess the innervation patterns in oral cancer using the general neuronal marker protein gene product 9.5 (PGP 9.5) and to find an explanation for why oral cancer tends to be painless in the early stages.
Tumor tissue from 30 unselected patients with oral squamous cell carcinoma was evaluated for this study. PGP 9.5 was used to localize nerve fibers in oral squamous cell carcinoma. An indirect immunofluorescence technique using biotin/FITC streptavidin detection system was used on paraffin wax sections of tumor tissue fixed in neutral buffered formalin.
There was no PGP9.5 immunoreactivity in the normal tissue adjacent to the tumor in 18 cases out of 30 (60%). In 12/30 of oral squamous cell carcinoma, preexisting nerve fibers were detected in tissue stroma adjacent to the cancer tissue. Labeled nerve fibers between tumor cells were detected only in 2 out of the 30 cases.
There are no apparent patterns of innervations in the cancer tissues themselves, but there are innervations patterns in the surrounding tissue, which presumably represents preexisting nerves. These results may partly explain why oral cancer tends to be painless in the early stages.
Url:
DOI: 10.4103/0973-029X.92967
PubMed: 22434940
PubMed Central: 3303516
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003251
Links to Exploration step
PMC:3303516Curation
No country items
Fahed Samir Habash<affiliation><nlm:aff id="aff1">Head Department of Oral Surgery, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff2">Head Department of Prosthodontics and Restorative Dentistry, Faculty of Dentistry, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff3">Dean of Dentistry, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of the innervation pattern of oral squamous cell carcinoma using neural protein gene product (9.5)–An immunocytochemical study</title><author><name sortKey="Habash, Fahed Samir" sort="Habash, Fahed Samir" uniqKey="Habash F" first="Fahed Samir" last="Habash">Fahed Samir Habash</name><affiliation><nlm:aff id="aff1">Head Department of Oral Surgery, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation></author><author><name sortKey="Hantash, Ra D O Abu" sort="Hantash, Ra D O Abu" uniqKey="Hantash R" first="Ra D O Abu" last="Hantash">Ra D O Abu Hantash</name><affiliation><nlm:aff id="aff2">Head Department of Prosthodontics and Restorative Dentistry, Faculty of Dentistry, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation></author><author><name sortKey="Yunis, Mohammed Abu" sort="Yunis, Mohammed Abu" uniqKey="Yunis M" first="Mohammed Abu" last="Yunis">Mohammed Abu Yunis</name><affiliation><nlm:aff id="aff3">Dean of Dentistry, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22434940</idno><idno type="pmc">3303516</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303516</idno><idno type="RBID">PMC:3303516</idno><idno type="doi">10.4103/0973-029X.92967</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">003251</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003251</idno><idno type="wicri:Area/Pmc/Curation">003251</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003251</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Assessment of the innervation pattern of oral squamous cell carcinoma using neural protein gene product (9.5)–An immunocytochemical study</title><author><name sortKey="Habash, Fahed Samir" sort="Habash, Fahed Samir" uniqKey="Habash F" first="Fahed Samir" last="Habash">Fahed Samir Habash</name><affiliation><nlm:aff id="aff1">Head Department of Oral Surgery, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation></author><author><name sortKey="Hantash, Ra D O Abu" sort="Hantash, Ra D O Abu" uniqKey="Hantash R" first="Ra D O Abu" last="Hantash">Ra D O Abu Hantash</name><affiliation><nlm:aff id="aff2">Head Department of Prosthodontics and Restorative Dentistry, Faculty of Dentistry, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation></author><author><name sortKey="Yunis, Mohammed Abu" sort="Yunis, Mohammed Abu" uniqKey="Yunis M" first="Mohammed Abu" last="Yunis">Mohammed Abu Yunis</name><affiliation><nlm:aff id="aff3">Dean of Dentistry, Al Quds University, Jerusalem, Palestine</nlm:aff><wicri:noCountry code="subfield">Palestine</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of Oral and Maxillofacial Pathology : JOMFP</title><idno type="ISSN">0973-029X</idno><idno type="eISSN">1998-393X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>This study was carried out to assess the innervation patterns in oral cancer using the general neuronal marker protein gene product 9.5 (PGP 9.5) and to find an explanation for why oral cancer tends to be painless in the early stages.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Tumor tissue from 30 unselected patients with oral squamous cell carcinoma was evaluated for this study. PGP 9.5 was used to localize nerve fibers in oral squamous cell carcinoma. An indirect immunofluorescence technique using biotin/FITC streptavidin detection system was used on paraffin wax sections of tumor tissue fixed in neutral buffered formalin.</p></sec><sec id="st3"><title>Results:</title><p>There was no PGP9.5 immunoreactivity in the normal tissue adjacent to the tumor in 18 cases out of 30 (60%). In 12/30 of oral squamous cell carcinoma, preexisting nerve fibers were detected in tissue stroma adjacent to the cancer tissue. Labeled nerve fibers between tumor cells were detected only in 2 out of the 30 cases.</p></sec><sec id="st4"><title>Conclusion:</title><p>There are no apparent patterns of innervations in the cancer tissues themselves, but there are innervations patterns in the surrounding tissue, which presumably represents preexisting nerves. These results may partly explain why oral cancer tends to be painless in the early stages.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kurtz, Ka" uniqKey="Kurtz K">KA Kurtz</name></author><author><name sortKey="Hoffman, Ht" uniqKey="Hoffman H">HT Hoffman</name></author><author><name sortKey="Zimmerman, Mb" uniqKey="Zimmerman M">MB Zimmerman</name></author><author><name sortKey="Robinson, Ra" uniqKey="Robinson R">RA Robinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mendenhall, Wm" uniqKey="Mendenhall W">WM Mendenhall</name></author><author><name sortKey="Amdur, Rj" uniqKey="Amdur R">RJ Amdur</name></author><author><name sortKey="Williams, Ls" uniqKey="Williams L">LS Williams</name></author><author><name sortKey="Mancuso, Aa" uniqKey="Mancuso A">AA Mancuso</name></author><author><name sortKey="Stringer, Sp" uniqKey="Stringer S">SP Stringer</name></author><author><name sortKey="Price Mendenhall, N" uniqKey="Price Mendenhall N">N Price Mendenhall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fagan, Jj" uniqKey="Fagan J">JJ Fagan</name></author><author><name sortKey="Collins, B" uniqKey="Collins B">B Collins</name></author><author><name sortKey="Barnes, L" uniqKey="Barnes L">L Barnes</name></author><author><name sortKey="D Mico, F" uniqKey="D Mico F">F D’Amico</name></author><author><name sortKey="Myers, En" uniqKey="Myers E">EN Myers</name></author><author><name sortKey="Johnson, Jt" uniqKey="Johnson J">JT Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Penfold, Cn" uniqKey="Penfold C">CN Penfold</name></author><author><name sortKey="Partridge, M" uniqKey="Partridge M">M Partridge</name></author><author><name sortKey="Rojas, R" uniqKey="Rojas R">R Rojas</name></author><author><name sortKey="Langdon, Jd" uniqKey="Langdon J">JD Langdon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, Jk" uniqKey="Williams J">JK Williams</name></author><author><name sortKey="Carlson, Gw" uniqKey="Carlson G">GW Carlson</name></author><author><name sortKey="Cohen, C" uniqKey="Cohen C">C Cohen</name></author><author><name sortKey="Derose, Pb" uniqKey="Derose P">PB Derose</name></author><author><name sortKey="Hunter, S" uniqKey="Hunter S">S Hunter</name></author><author><name sortKey="Jurkiewicz, Mj" uniqKey="Jurkiewicz M">MJ Jurkiewicz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitchell, Bs" uniqKey="Mitchell B">BS Mitchell</name></author><author><name sortKey="Schumacher, U" uniqKey="Schumacher U">U Schumacher</name></author><author><name sortKey="Kaiserling, E" uniqKey="Kaiserling E">E Kaiserling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schumacher, U" uniqKey="Schumacher U">U Schumacher</name></author><author><name sortKey="Adam, E" uniqKey="Adam E">E Adam</name></author><author><name sortKey="Flavell, Da" uniqKey="Flavell D">DA Flavell</name></author><author><name sortKey="Boehm, D" uniqKey="Boehm D">D Boehm</name></author><author><name sortKey="Loizidou, M" uniqKey="Loizidou M">M Loizidou</name></author><author><name sortKey="Brooks, S" uniqKey="Brooks S">S Brooks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coindre, Jm" uniqKey="Coindre J">JM Coindre</name></author><author><name sortKey="De Mascarel, A" uniqKey="De Mascarel A">A de Mascarel</name></author><author><name sortKey="Trojani, M" uniqKey="Trojani M">M Trojani</name></author><author><name sortKey="De Mascarel, I" uniqKey="De Mascarel I">I de Mascarel</name></author><author><name sortKey="Pages, A" uniqKey="Pages A">A Pages</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alm, P" uniqKey="Alm P">P Alm</name></author><author><name sortKey="Lundberg, Lm" uniqKey="Lundberg L">LM Lundberg</name></author><author><name sortKey="Wharton, J" uniqKey="Wharton J">J Wharton</name></author><author><name sortKey="Polak, Jm" uniqKey="Polak J">JM Polak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Springall, Dr" uniqKey="Springall D">DR Springall</name></author><author><name sortKey="Lackie, P" uniqKey="Lackie P">P Lackie</name></author><author><name sortKey="Levene, Mm" uniqKey="Levene M">MM Levene</name></author><author><name sortKey="Marangos, Pj" uniqKey="Marangos P">PJ Marangos</name></author><author><name sortKey="Polak, Jm" uniqKey="Polak J">JM Polak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bishop, Ae" uniqKey="Bishop A">AE Bishop</name></author><author><name sortKey="Polak, Jm" uniqKey="Polak J">JM Polak</name></author><author><name sortKey="Facer, P" uniqKey="Facer P">P Facer</name></author><author><name sortKey="Ferri, Gl" uniqKey="Ferri G">GL Ferri</name></author><author><name sortKey="Marangos, Pj" uniqKey="Marangos P">PJ Marangos</name></author><author><name sortKey="Pearse, Ag" uniqKey="Pearse A">AG Pearse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hacker, Gw" uniqKey="Hacker G">GW Hacker</name></author><author><name sortKey="Polak, Jm" uniqKey="Polak J">JM Polak</name></author><author><name sortKey="Springall, Dr" uniqKey="Springall D">DR Springall</name></author><author><name sortKey="Ballesta, J" uniqKey="Ballesta J">J Ballesta</name></author><author><name sortKey="Cadieux, A" uniqKey="Cadieux A">A Cadieux</name></author><author><name sortKey="Gu, J" uniqKey="Gu J">J Gu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, Po" uniqKey="Wilson P">PO Wilson</name></author><author><name sortKey="Barber, Pc" uniqKey="Barber P">PC Barber</name></author><author><name sortKey="Hamid, Qa" uniqKey="Hamid Q">QA Hamid</name></author><author><name sortKey="Power, Bf" uniqKey="Power B">BF Power</name></author><author><name sortKey="Dhillon, Ap" uniqKey="Dhillon A">AP Dhillon</name></author><author><name sortKey="Rode, J" uniqKey="Rode J">J Rode</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lundberg, Lm" uniqKey="Lundberg L">LM Lundberg</name></author><author><name sortKey="Alm, P" uniqKey="Alm P">P Alm</name></author><author><name sortKey="Wharton, J" uniqKey="Wharton J">J Wharton</name></author><author><name sortKey="Polak, Jm" uniqKey="Polak J">JM Polak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maeda, T" uniqKey="Maeda T">T Maeda</name></author><author><name sortKey="Honma, S" uniqKey="Honma S">S Honma</name></author><author><name sortKey="Takano, Y" uniqKey="Takano Y">Y Takano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garzino, M" uniqKey="Garzino M">M Garzino</name></author><author><name sortKey="Ramieri, G" uniqKey="Ramieri G">G Ramieri</name></author><author><name sortKey="Panzica, G" uniqKey="Panzica G">G Panzica</name></author><author><name sortKey="Preti, G" uniqKey="Preti G">G Preti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trojanowski, Jq" uniqKey="Trojanowski J">JQ Trojanowski</name></author><author><name sortKey="Lee, Vm" uniqKey="Lee V">VM Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coggi, G" uniqKey="Coggi G">G Coggi</name></author><author><name sortKey="Dell Orto, P" uniqKey="Dell Orto P">P Dell Orto</name></author><author><name sortKey="Vial, G" uniqKey="Vial G">G Vial</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bancroft, Jd" uniqKey="Bancroft J">JD Bancroft</name></author><author><name sortKey="Cook, Hc" uniqKey="Cook H">HC Cook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fantini, F" uniqKey="Fantini F">F Fantini</name></author><author><name sortKey="Giannetti, A" uniqKey="Giannetti A">A Giannetti</name></author><author><name sortKey="Benassi, L" uniqKey="Benassi L">L Benassi</name></author><author><name sortKey="Cattaneo, V" uniqKey="Cattaneo V">V Cattaneo</name></author><author><name sortKey="Magnoni, C" uniqKey="Magnoni C">C Magnoni</name></author><author><name sortKey="Pincelli, C" uniqKey="Pincelli C">C Pincelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schofield, Jn" uniqKey="Schofield J">JN Schofield</name></author><author><name sortKey="Day, In" uniqKey="Day I">IN Day</name></author><author><name sortKey="Thompson, Rj" uniqKey="Thompson R">RJ Thompson</name></author><author><name sortKey="Edwards, Yh" uniqKey="Edwards Y">YH Edwards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schumacher, U" uniqKey="Schumacher U">U Schumacher</name></author><author><name sortKey="Mitchell, Bs" uniqKey="Mitchell B">BS Mitchell</name></author><author><name sortKey="Kaiserling, E" uniqKey="Kaiserling E">E Kaiserling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Noorden, S" uniqKey="Van Noorden S">S Van Noorden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pogue, Km" uniqKey="Pogue K">KM Pogue</name></author><author><name sortKey="Johnston, Cf" uniqKey="Johnston C">CF Johnston</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Oral Maxillofac Pathol</journal-id><journal-id journal-id-type="publisher-id">JOMFP</journal-id><journal-title-group><journal-title>Journal of Oral and Maxillofacial Pathology : JOMFP</journal-title></journal-title-group><issn pub-type="ppub">0973-029X</issn><issn pub-type="epub">1998-393X</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22434940</article-id><article-id pub-id-type="pmc">3303516</article-id><article-id pub-id-type="publisher-id">JOMFP-16-16</article-id><article-id pub-id-type="doi">10.4103/0973-029X.92967</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Assessment of the innervation pattern of oral squamous cell carcinoma using neural protein gene product (9.5)–An immunocytochemical study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Habash</surname><given-names>Fahed Samir</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Hantash</surname><given-names>Ra’ed O Abu</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib><contrib contrib-type="author"><name><surname>Yunis</surname><given-names>Mohammed Abu</given-names></name><xref ref-type="aff" rid="aff3">2</xref></contrib></contrib-group><aff id="aff1">Head Department of Oral Surgery, Al Quds University, Jerusalem, Palestine</aff><aff id="aff2"><label>1</label>Head Department of Prosthodontics and Restorative Dentistry, Faculty of Dentistry, Al Quds University, Jerusalem, Palestine</aff><aff id="aff3"><label>2</label>Dean of Dentistry, Al Quds University, Jerusalem, Palestine</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold><italic> Dr. Fahed S Habash, Department of Oral Surgery, Al Quds University, Jerusalem, P.O. Box - 20002, Palestine <email xlink:href="fahedhabash@hotmail.com">fahedhabash@hotmail.com</email></italic></corresp></author-notes><pub-date pub-type="ppub"><season>Jan-Apr</season><year>2012</year></pub-date><volume>16</volume><issue>1</issue><fpage>16</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright: © Journal of Oral and Maxillofacial Pathology</copyright-statement><copyright-year>2012</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Background:</title><p>This study was carried out to assess the innervation patterns in oral cancer using the general neuronal marker protein gene product 9.5 (PGP 9.5) and to find an explanation for why oral cancer tends to be painless in the early stages.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Tumor tissue from 30 unselected patients with oral squamous cell carcinoma was evaluated for this study. PGP 9.5 was used to localize nerve fibers in oral squamous cell carcinoma. An indirect immunofluorescence technique using biotin/FITC streptavidin detection system was used on paraffin wax sections of tumor tissue fixed in neutral buffered formalin.</p></sec><sec id="st3"><title>Results:</title><p>There was no PGP9.5 immunoreactivity in the normal tissue adjacent to the tumor in 18 cases out of 30 (60%). In 12/30 of oral squamous cell carcinoma, preexisting nerve fibers were detected in tissue stroma adjacent to the cancer tissue. Labeled nerve fibers between tumor cells were detected only in 2 out of the 30 cases.</p></sec><sec id="st4"><title>Conclusion:</title><p>There are no apparent patterns of innervations in the cancer tissues themselves, but there are innervations patterns in the surrounding tissue, which presumably represents preexisting nerves. These results may partly explain why oral cancer tends to be painless in the early stages.</p></sec></abstract><kwd-group><kwd>Indirect immunofluorescence technique</kwd><kwd>oral squamous cell carcinoma</kwd><kwd>tumor innervation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003251 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 003251 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:3303516
|texte= Assessment of the innervation pattern of oral squamous cell carcinoma using neural protein gene product (9.5)–An immunocytochemical study
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:22434940" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |